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ACAAI > Patients & Public > Resources > Ask the Allergist

Treating Hives From a Drug Allergy

Q: How long does it usually take for hives to disappear after a reaction to a drug?  With the use of Benadryl?

A: With a drug reactions hives can persist for several days even with Benadryl.  The severity and duration of drug reactions varies between individuals and the inciting drug.  Sometimes prednisone is required to treat the reaction depending on the severity.  It would be prudent for any individual experiencing a suspected drug reaction to see a qualified allergist for evaluation and acute and chronic treatment.

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